论文部分内容阅读
机械力刺激能够诱发机体中包括牙周组织在内的多种组织发生无菌性炎症反应,并能促进免疫细胞以及一些非免疫细胞如牙周膜细胞发生焦亡(pyroptosis)。现有研究表明,Gasdermin-D(GSDMD)在炎症反应、细胞焦亡发生中具有重要作用,但GSDMD是否参与机械力刺激引发的炎症反应和细胞焦亡尚未可知。综述机械力刺激诱导机体组织炎症反应以及焦亡的信号通路研究进展。
Mechanical stimulation can induce aseptic inflammation in many tissues, including periodontal tissues, and promote pyroptosis in immune cells and some non-immune cells such as periodontal ligament cells. Previous studies have shown that Gasdermin-D (GSDMD) plays an important role in the inflammatory response and cell apoptosis, but it is unknown whether GSDMD participates in inflammation and cell death induced by mechanical stimulation. This review summarizes the research progress of mechanical stimulation on the inflammation of body tissues and the signaling pathway of focal apoptosis.