Sirtuns are class Ⅲ histone deacetylase (HDAC), and their activity is dependence on NAD+.Except for deacetylating histones, Sirtuins are also interacted with m
Transforming growth factor β (TGF-β) is a potent anti-proliferative factor in multiple types of cells.Deregulation of TGF-β signaling is associated with deve