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目前,细菌性脑膜炎的病死率仍然很高,青霉素对该病的预后也无实质性的改善,且幸存者(特别是婴幼儿)往往留有后遗症。为此,作者研究了氨苄青霉素和皮质激素对实验性肺炎球菌性脑膜炎的脑水含量、脑脊液压力及乳酸浓度的作用。作者采用了实验性感染肺炎球菌性脑膜炎的家兔为动物模型,以说明感染对脑水含量、颅内压和乳酸形成的影响,并检查了这些参数对氨苄青霉素和皮质激素(甲基强的松龙和地塞米松)治疗的反应。
At present, the mortality rate of bacterial meningitis is still high, and the prognosis of the disease is not substantially improved by penicillin. Survivors (especially infants and young children) often have sequelae. To this end, the authors studied the effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure and lactate concentration in experimental pneumococcal meningitis. The authors used an experimental rabbit infected with pneumococcal meningitis as an animal model to demonstrate the effect of infection on brain water content, intracranial pressure and lactate formation and examined the effect of these parameters on ampicillin and corticosteroids Of prednisone and dexamethasone).