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了解肝炎患者胃粘膜组织中乙型肝炎病毒（ＨＢＶ）和丙型肝炎病毒（ＨＣＶ）的感染状况。采用免疫组化Ｓ－Ｐ法以抗－ＨＣＶＮＳ３单克隆抗体及抗－ＨＢｓ、抗－ＨＢｃ多克隆抗体对３３例慢性丙型肝炎患者胃粘膜组织中ＨＢＶ和ＨＣＶ进行了检测。同时还用双标记技术对二种抗原进行了双重染色以了解其在胃粘膜细胞中的分布。ＨＣＶＮＳ３、ＨＢｓＡｇ及ＨＢｃＡｇ的检出率分别为３３．３３％（１１／３３）、４８．４８％（１６／３３）、１２．１２％（４／３３）。ＨＢｓＡｇ、ＨＣＶＮＳ３Ａｇ主要位于腺体细胞的胞浆中，而ＨＢｃＡｇ主要在细胞核中表达。阳性细胞呈单个、片状或簇样分布。慢性肝炎患者的胃粘膜组织中存在ＨＣＶ和ＨＢＶ的感染。二种肝炎病毒与胃粘膜病变的关系值得进一步探讨。
To understand the infection status of hepatitis B virus (HBV) and hepatitis C virus (HCV) in gastric mucosa of hepatitis patients. Immunohistochemical S-P method with anti-HCV NS3 monoclonal antibody and anti-HBs, anti-HBc polyclonal antibody in patients with chronic hepatitis C in patients with gastric mucosal HBV and HCV were detected. At the same time, we double-stained the two kinds of antigens with double labeling technique to know their distribution in gastric mucosal cells. The detection rates of HCVNS3, HBsAg and HBcAg were 33.33% (11/33), 48.48% (16/33) and 12.12% (4/33) respectively. HBsAg, HCVNS3Ag mainly located in the cytoplasm of glandular cells, while HBcAg is mainly expressed in the nucleus. Positive cells were single, flaky or cluster-like distribution. Chronic hepatitis patients with gastric and mucosal tissue HCV and HBV infection. Two kinds of hepatitis virus and gastric mucosal lesions worthy of further study.