在关于肿瘤逃逸免疫系统控制的机理研究中,人们比较注重于研究自发性肿瘤的免疫原性低下以及宿主的免疫功能不全。而对于肿瘤病灶的解剖学特征及其可能限制宿主与肿瘤细胞间的相互作用、从而阻碍免疫治疗及其他治疗方法的效果这一可能性较少关注。最近有人发现,血流中的抗瘤抗体并不能均匀地透过,并分布于实体瘤的所有生长部位,而只限于分布在肿瘤血管分布丰富的、或出血性的部位。而抗体不能透入所有肿瘤的部位与肿瘤继免疫攻击后继续存活往往是有关的。化疗药物等其他一些血行物质也可能遭遇同样的障碍,因而不能迅速布散于肿瘤的所有部位。这一发现提示了,采用联合的治疗方法,包括解 In the study of the mechanism of control of tumor escape immune system, people pay more attention to the study of the immunogenicity of the spontaneous tumor and the host’s immune dysfunction. However, less attention is paid to the possibility of anatomical features of tumor lesions and their potential to limit the interaction between the host and tumor cells, thereby impeding the effectiveness of immunotherapy and other treatments. It was recently discovered that anti-tumor antibodies in the blood stream do not penetrate evenly and are distributed on all growth sites of solid tumors, but are only distributed in areas where the blood vessels of tumors are abundantly distributed or hemorrhagic. The site where antibodies cannot penetrate into all tumors is often related to the survival of tumors following an immune attack. Other blood-borne substances, such as chemotherapy drugs, may also encounter the same obstacles and cannot be quickly dispersed in all parts of the tumor. This finding suggests that using a combination of treatments, including solutions