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目的 :探讨米非司酮配伍米索前列醇终止早孕的疗效。方法 :孕 5～ 8周 ,182 0例终止早孕妇女、应用米非司酮片 2 5mg每天 2次× 3d ,第 4天口服米索前列醇片 6 0 0 μg ,留观 2～ 6h或 6h以上。结果 :完全流产率91.4 3% ,不全流产 7.14 % ,失败 1.4 3% ,孕龄越小成功率越高。 (P <0 .0 0 1)孕卵于加药后 6h内排出 ,占77.14 % ,出血量 10 0～ 2 0 0ml占 90 .71% ,平均出血量 10 6 .4ml。出血时间≤ 1周占 14 .2 9% ,≥ 2周占 5 1.4 3%。结论 :米非司酮配伍米索前列醇用于终止早孕是一成功率高、安全方便的方法 ,但流产后存在着出血量偏多、出血时间偏长等问题 ,需进一步研究解决。
Objective: To investigate the efficacy of mifepristone combined with misoprostol to terminate early pregnancy. Methods: Pregnant women aged from 5 to 8 weeks were enrolled in this study. One hundred and eighty eight women with early pregnancies were terminated. Mifepristone was given 25mg twice daily for 3 days, and on the 4th day oestromethorphan was taken as 600μg orally for 2-6h or 6h the above. Results: Complete abortion rate of 91.4 3%, incomplete abortion 7.14%, failure 1.4 3%, the smaller the gestational age, the higher the success rate. (P0.01). The eggs were discharged within 6h after dosing, accounting for 77.14%. The amount of bleeding was 100.7% and the average amount of bleeding was 106.6ml. Bleeding time ≤ 1 week accounted for 14.29%, ≥ 2 weeks accounted for 5 1.4 3%. Conclusion: The combination of mifepristone and misoprostol for termination of early pregnancy is a safe, convenient and successful method. However, after the abortion, there are some problems such as excessive bleeding, long bleeding time and so on, which need to be further studied and resolved.