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目的：探讨金属硫蛋白（ＭＴ）在心肌梗塞和缺血再灌注心肌损伤修复中与脂质过氧化的关系。方法：采用大鼠心肌梗塞／缺血再灌注模型，测定手术后２４ｈ和８周心肌组织的ＭＴ及脂质过氧化的中间产物丙二醛（ＭＤＡ）的含量。结果：心肌梗塞和缺血再灌注２４ｈ后ＭＤＡ含量均显著高于对照组（Ｐ＜０．０１），８周后ＭＤＡ显著降低（Ｐ＜０．０５）；而ＭＴ的含量在术后２４ｈ即升高，８周ＭＴ继续升高，缺血再灌注组ＭＴ达（３１４０９±２３１８）ｎｇ／ｍｇ蛋白。结论：ＭＴ对心肌梗塞和缺血再灌注所产生的脂质过氧化产物可能具有清除作用，从而促进损伤心肌的修复。
Objective: To investigate the relationship between the expression of metallothionein (MT) and lipid peroxidation in myocardial infarction and ischemia-reperfusion myocardial injury. Methods: The levels of MT and lipid peroxidation malondialdehyde (MDA) in myocardial tissue were determined at 24h and 8h after operation by myocardial infarction / ischemia / reperfusion in rats. Results: The contents of MDA in myocardial infarction and ischemia-reperfusion 24h groups were significantly higher than those in control group (P <0.01), and MDA levels were significantly decreased after 8 weeks (P <0.05) MT increased at 8 weeks, MT reached (31409 ± 2318) ng / mg protein in ischemia-reperfusion group. CONCLUSION: MT may have a scavenging effect on lipid peroxidation products produced by myocardial infarction and ischemia-reperfusion, thereby promoting the repair of injured myocardium.