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目的探讨抑制素(INH)与表皮生长因子(EGF)在妊娠期高血压疾病发病中的变化及意义。方法取2004-10-2005-03在解放军沈阳202医院妇产科住院单胎、剖宫产分娩65例妊娠期高血压疾病患者及21例正常妊娠妇女血浆,采用酶联免疫吸附技术(ELISA)测定其血浆中INH及EGF水平。结果妊娠期高血压疾病患者血浆INH质量浓度为(498·76±52·26)ng/L,明显高于对照组(421·26±36·33)ng/L,差异有显著性意义(P<0·01)。妊娠期高血压疾病患者血浆EGF质量浓度为(407·79±59·58)ng/L,明显低于对照组(463·07±87·00)ng/L,差异有显著性意义(P<0·05)。结论孕妇血浆中INH水平升高、EGF水平下降可能与妊娠期高血压疾病的发病及病情轻重有关。
Objective To investigate the changes and significance of inhibin (INH) and epidermal growth factor (EGF) in the pathogenesis of hypertensive disorder complicating pregnancy. Methods Totally 65 pregnant women with gestational hypertension and 21 normal pregnant women were hospitalized in Shenyang 202 Hospital of PLA from 2004-10-2005-03. Plasma samples were collected by enzyme-linked immunosorbent assay (ELISA) The plasma levels of INH and EGF were measured. Results The plasma INH concentration in patients with gestational hypertension was (498 · 76 ± 52 · 26) ng / L, which was significantly higher than that of the control group (421 · 26 ± 36 · 33) ng / L, with significant difference (P <0 · 01). The plasma EGF level in patients with gestational hypertension was (407 · 79 ± 59 · 58) ng / L, which was significantly lower than that in the control group (463.07 ± 87.00 ng / L, P < 0 · 05). Conclusions The level of INH in plasma of pregnant women is elevated and the decrease of EGF level may be related to the incidence and severity of hypertensive disorders in pregnancy.