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循环微粒(circulate microparticle,cMP)是细胞激活、损伤或凋亡后从细胞膜脱落的直径小于lμm的小囊泡,在糖尿病、心血管疾病、艾滋病、慢性炎症性疾病中发现循环微粒水平升高,且它的一些生物学活性(如细胞间生物活性信号的传导、免疫调节、血管生成、组织修复等)与疾病的发生、发展息息相关。对于它的认识还在不断地探索,其研究也越来越多,因此,本文主要就cMP的研究进展进行综述。
Circulating microparticles (cMP) are small vesicles less than 1 μm in diameter that fall off the cell membrane after cell activation, injury or apoptosis, and are found to have elevated levels of circulating particles in diabetes, cardiovascular diseases, AIDS and chronic inflammatory diseases. And some of its biological activities (such as the signal transduction of biological activity among cells, immune regulation, angiogenesis, tissue repair, etc.) are closely related to the occurrence and development of the disease. The understanding of it is still being explored constantly, and its research is also more and more. Therefore, this article mainly reviews the research progress of cMP.