Objective To investigate the effects of phototherapy combined with albumin administration on hyperbilirubinemia in newbs.Methods Totally 64 newbs with neonatal hyperbilirubinemia were randomly divided into the control group and the study group,with 32 cases in each group.The newbs in control group received phototherapy and routine care,while those in study group were administrated with intravenous injection of albumin in addition to phototherapy and routine care.The concentration of total serum bilirubin,newbsbody weight and amount of milk intake were measured before and after phototherapy.Results There was a significant difference in the milk intake between two groups after phototherapy (P ＜ 0.05).There was no significant difference in the body weight or total serum bilirubin level of newbs between two groups after phototherapy (P ＞ 0.05).Conclusion Combined application of phothotherapy and albumin administration on neonatal hyperbilirubinemia could promote the newbs appetite and improve the recovery of the neonates,but the effect on reducing blood bilirubin level and weight gain needs further study.