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目的:探讨CT引导水冷循环微波消融联合放化疗治疗Ⅲ期周围型肺癌对患者相关血清因子(鳞状细胞癌相关抗原、细胞角蛋白19片段、中期因子)的影响。方法:选取我院就诊的184例Ⅲ期周围型肺癌患者,随机分为观察组(92例)和对照组(92例)。对照组给予CT引导水冷循环微波消融治疗,观察组给予CT引导水冷循环微波消融联合放化疗治疗。分别在两组患者的治疗前后检测血清鳞状细胞癌相关抗原、细胞角蛋白19片段、中期因子水平。结果:两组治疗后较治疗前血清SCC、CYFRA21-1、MK水平均明显降低(P<0.05);治疗后观察组血清SCC、CYFRA21-1、MK水平较对照组显著性的降低(P<0.05)。结论:CT引导水冷循环微波消融联合放化疗治疗Ⅲ期周围型肺癌能有效的降低患者血清SCC、CYFRA21-1、MK水平。
Objective: To investigate the effect of CT-guided microwave-assisted microwave ablation combined with chemoradiotherapy on patients with stage Ⅲ peripheral lung cancer and its related serum factors (squamous cell carcinoma-associated antigen, cytokeratin 19, midkine). Methods: A total of 184 patients with stage Ⅲ lung cancer who were treated in our hospital were randomly divided into observation group (92 cases) and control group (92 cases). The control group was given CT guided water-cooled microwave ablation, and the observation group was given CT guided water-cooled microwave ablation plus radiotherapy and chemotherapy. Serum squamous cell carcinoma-associated antigen, cytokeratin 19 fragment and midkine were detected before and after treatment in two groups. Results: The levels of SCC, CYFRA21-1 and MK were significantly decreased in both groups before and after treatment (P <0.05). After treatment, the levels of SCC, CYFRA21-1 and MK in the observation group were significantly lower than those in the control group (P < 0.05). Conclusion: CT-guided microwave-assisted microwave ablation combined with chemoradiotherapy for the treatment of stage Ⅲ lung cancer can effectively reduce the serum levels of SCC, CYFRA21-1 and MK.