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探讨核素肾动态显像和尿微量白蛋白检测对早期发现糖尿病肾病的临床意义。收集了内科诊断为II型糖尿病为主的住院病人60例,选择临床上无糖尿病和和高血压诊断的对照组20例,两组进行系列常规检查,并做同位素肾图检查来测定肾脏的肾小球滤过率(GFR),按病人的GFR测定值分为增高(>120 mL/min)、正常(70–120 mL/min)、降低(<70 mL/min)组。这些糖尿病人中高GFR者占8.33%(5/60),平均为141.98±13.60mg/min,比对照组增高35%,差异非常显著(P<0.01);GFR正常者占33.33%(20/60),平均为102.18±10.24mg/min,与对照组相比差异无显著性(P>0.05);GFR降低者占58.33%(35/60),平均为57.19±18.00 mg/min,比对照组降低54.3%,差异非常显著(P<0.01);同时三组病人的尿微量蛋白与对照组相比差异非常显著性(P<0.01)。结果显示,对于糖尿病患者定期联合检测尿微量白蛋白、尿β2-微球蛋白尿和GFR不仅有助于糖尿病肾病的早期诊断,而且还有助于糖尿病肾病的疗效监控和预后判断。
To investigate the clinical significance of radionuclide renal dynamic imaging and urine microalbumin detection in early detection of diabetic nephropathy. A total of 60 inpatients diagnosed as type II diabetes were collected. Twenty patients in the control group without diabetes and hypertension diagnosed clinically were enrolled in the study. The two groups were subjected to a series of routine examinations and isotope nephrograms were performed to determine the kidney The glomerular filtration rate (GFR) was assigned to increase (> 120 mL / min), normal (70-120 mL / min), and decrease (<70 mL / min) as measured by the patient’s GFR. The average GFR in these diabetic patients was 8.33% (5/60), with an average of 141.98 ± 13.60mg / min, which was 35% higher than that of the control group (P <0.01). The average GFR was 33.33% (20/60) ), With an average of 102.18 ± 10.24mg / min, no significant difference compared with the control group (P> 0.05); GFR decreased 58.33% (35/60) with an average of 57.19 ± 18.00 mg / min, (P <0.01). The urine microalbumin in the three groups was significantly different from the control group (P <0.01). The results showed that regular joint detection of urinary albumin, urinary β2-microglobulinuria and GFR not only contribute to the early diagnosis of diabetic nephropathy, but also help to monitor the efficacy and prognosis of diabetic nephropathy.