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目的:评价中药联合主动免疫对母-胎免疫识别低下型复发性流产的治疗效果。方法:全面检索中国知网全文期刊数据库、万方数据库、重庆维普中文科技期刊数据库、中国生物医学文献数据库,收集中药联合主动免疫与单纯主动免疫比较对母-胎免疫识别低下型复发性流产治疗效果的随机对照试验,对资料进行评价并用Revman 5.2进行meta分析。结果:符合纳入标准的研究有10例共763个患者。Meta分析结果显示中药联合主动免疫的妊娠成功率高于单纯主动免疫组(OR 3.31,95%[2.29,4.78],P<0.00001),差异有统计学意义。结论:中药联合主动免疫治疗母-胎免疫识别低下型复发性流产与单纯主动免疫相比妊娠成功率提高。
Objective: To evaluate the therapeutic effect of combined active immunization with traditional Chinese medicine on maternal-fetal immune recognition of low-grade recurrent spontaneous abortion. Methods: A comprehensive search of CNKI full-text periodicals database, Wanfang database, Chongqing Weipu Chinese scientific journals database, Chinese biomedical literature database, collection of traditional Chinese medicine combined with active immunization and simple active immunization for maternal-fetal immune recognition of low-grade recurrent abortion Randomized controlled trials of efficacy were used to evaluate the data and meta-analysis using Revman 5.2. RESULTS: A total of 763 patients were eligible for inclusion in 10 studies. The results of Meta analysis showed that the success rate of pregnancy with Chinese medicine combined with active immunization was higher than that of active immunization alone (OR 3.31, 95% [2.29,4.78], P <0.00001). The difference was statistically significant. Conclusions: The success rate of pregnancy in pregnant women with low-grade recurrent spontaneous abortion of mother-fetus immunocompromised as compared with that of active immunization alone.