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[摘要] 目的 探討非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)合并2型糖尿病(type 2 diabetes mellitus,T2DM)患者的临床特征及其相关危险因素。 方法 选取我院门诊2015年12月~2018年12月NAFLD 188例患者作为研究对象;采用分组依据:188例NAFLD按照是否合并T2DM分为两组:NAFLD合并T2DM组102例,单纯NAFLD组86例。比较两组患者的体质量指数(Body mass index,BMI)、空腹血糖(Glucose, GLU)、糖化血红蛋白(glycosylated hemoglobin,HbAlc)、血脂指标、肝功能及肾功能等相关指标,以Logistic回归分析NAFLD合并T2DM的相关危险因素。 结果 NAFLD合并T2DM组患者尿酸(uric acid,UA)、γ-谷氨酰转移酶(gamma-Glutamyltransferase,GGT)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein-C,LDL-C)、GLU及HbAlc等各指标均较单纯NAFLD组升高,差异均有统计学意义(P<0.05);高密度脂蛋白胆固醇(high density lipoprotein-C,HDL-C)较单纯NAFLD组降低,差异有统计学意义(P<0.05)。以NAFLD是否合并T2DM为因变量,以UA、GGT、TC、TG、HDL-C、LDL-C、GLU及HbAlc为自变量,Logistic回归分析结果提示:TG(β=5.693,OR=2.826E5,95%CI=1.749E4~5.312E6)、UA(β=10.641,OR=4.581E7,95%CI=2.106E6~6.539E10)、GGT(β=6.487,OR=3.124E6,95%CI=1.346E4~1.248E8)是NAFLD患者罹患、合并T2DM的独立危险因素。 结论 NAFLD合并T2DM在临床上呈现出更严重的肝脏炎症、血脂升高及代谢紊乱。UA、GGT、TG可能是NAFLD合并T2DM的危险因素。
[关键词] 非酒精性脂肪肝;2型糖尿病;危险因素;γ-谷氨酰转移酶;尿酸;甘油三酯
[Abstract] Objective To investigate the clinical features and related risk factors of patients with non-alcoholic fatty liver disease(NAFLD) complicated with type 2 diabetes mellitus(T2DM). Methods A total of 188 patients with NAFLD in the outpatient clinic from December 2015 to December 2018 were enrolled in our hospital. 188 patients with NAFLD were divided into
[关键词] 非酒精性脂肪肝;2型糖尿病;危险因素;γ-谷氨酰转移酶;尿酸;甘油三酯
[Abstract] Objective To investigate the clinical features and related risk factors of patients with non-alcoholic fatty liver disease(NAFLD) complicated with type 2 diabetes mellitus(T2DM). Methods A total of 188 patients with NAFLD in the outpatient clinic from December 2015 to December 2018 were enrolled in our hospital. 188 patients with NAFLD were divided into