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大黄蒽醌衍生物大黄酸、大黄素和芦荟大黄素(40mg/kg·d×7ip)延长P388白血病小鼠存活期,分别为61%,47%和36%,腹水量和癌细胞数也相应减少。[~3H]TdR、[~3H]Urd及[~3H]Leu参入试验表明,大黄酸、大黄素和芦荟大黄素明显抑制P388癌细胞DNA、RNA和蛋白质的生物合成,呈剂量依从性。抑制(~3H)TdR的IC_(50)分别为65,55和79μg/ml;对(~3H)Urd的IC_(50)分别为46,50和80μg/ml;对(~3H)Leu的IC_(50)为58,75和88μg/ml。表明大黄酸和大黄素的抑制作用较强,芦荟大黄素次之。
The rhubarb aglycone derivatives rhein, emodin, and aloe-emodin (40 mg/kg·d×7ip) prolonged the survival of P388 leukemia mice, which were 61%, 47%, and 36%, respectively, and the amount of ascites and cancer cells were also corresponding. cut back. [~3H]TdR, [~3H]Urd, and [~3H]Leu incorporation tests showed that rhein, emodin, and aloe-emodin inhibited the biosynthesis of DNA, RNA, and protein in P388 cells, showing dose-dependent properties. IC50 of (~3H)TdR were 65, 55, and 79 μg/ml, respectively; IC 50 of (~3H)Urd were 46, 50, and 80 μg/ml, respectively; IC_ (~3H) Leu (50) were 58, 75 and 88 μg/ml. It showed that the inhibitory effect of rhein and emodin was stronger, followed by aloe emodin.