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目的探讨多聚腺苷二磷酸核糖聚合酶(PARP)及脂蛋白相关磷脂酶A2(Lp-PLA2)在子痫前期发病中可能的致病机制。方法选择2013年9月至2014年5月在中国医科大学附属盛京医院行剖宫产终止妊娠的妊娠晚期女性60例,根据是否存在子痫前期,将研究对象分为:子痫前期组32例(A组)以及正常孕妇组28例(B组)。采集孕妇肘前静脉血浆2 m L并应用酶联免疫分析法进行PARP及Lp-PLA2活性测量。结果 A组PARP、Lp-PLA2活性表达均显著高于B组(P<0.01)。PARP与Lp-PLA2活性呈正相关(r=0.234,P<0.01)。PARP活性与新生儿1 min Apgar评分、新生儿5 min Apgar评分存在相关性(r值分别为-0.243、-0.318,均P<0.05)。Lp-PLA2活性与孕妇收缩压、舒张压、脉压差、平均动脉压及新生儿5 min Apgar评分存在相关性(r值分别为0.342、0.335、0.245、0.351、-0.267,均P<0.05)。结论子痫前期患者体内存在PARP、Lp-PLA2的高活性表达,血浆PARP、Lp-PLA2可能参与了子痫前期的致病过程,且PARP及Lp-PLA2的高活性有可能对新生儿不良妊娠结局有一定预测作用。
Objective To investigate the possible pathogenic mechanism of poly (ADP-ribose) polymerase (PARP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) in the pathogenesis of preeclampsia. Methods From September 2013 to May 2014, 60 pregnant women of the third trimester who had cesarean termination of pregnancy at Shengjing Hospital of China Medical University from September 2013 to May 2014 were divided into three groups according to the presence or absence of preeclampsia: preeclampsia group 32 Cases (A group) and normal pregnant women group of 28 cases (B group). Pregnant elbow venous blood samples were collected 2 m L and enzyme-linked immunosorbent assay PARP and Lp-PLA2 activity measurements. Results The expressions of PARP and Lp-PLA2 in group A were significantly higher than those in group B (P <0.01). PARP and Lp-PLA2 activity was positively correlated (r = 0.234, P <0.01). There was a correlation between PARP activity and Apgar score at 1 minute in newborns and Apgar score at 5 minutes in neonates (r = -0.243, -0.318, all P <0.05). Lp-PLA2 activity correlated with systolic blood pressure, diastolic blood pressure, pulse pressure, mean arterial pressure and 5-minute Apgar score in neonates (r = 0.342,0.335,0.245,0.351, -0.267, all P <0.05) . Conclusions The expression of PARP and Lp-PLA2 is highly expressed in preeclampsia patients. The plasma PARP and Lp-PLA2 may be involved in the pathogenesis of preeclampsia. And the high activity of PARP and Lp-PLA2 may affect the neonatal adverse pregnancy The outcome has a certain predictive effect.