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至今,得到鉴定并纯化的具有谱系限制性的造血生长因子有12种(它们是Epo、GM-CSF、M-CSF、G-CSF、IL-I、IL-2、IL-3、IL-4、IL-5、IL-6、IL-7和ILF,ILF叫做白血病抑制因子一译者注)。由于分离出了它们相应的cDNA,应用基因工程方法可以大量地生产具有完整生物学活性的重组的生长因子,目前已使其中的Epo、GM-CSF和G-CSF得以进行广泛的临床试验。有证据表明,大量使用这三种因子在病人体内能刺激血细胞钠形成,不仅能选择性调节成熟血细胞的生成,而且还能刺激成熟细胞具备更强的功能活性。在小鼠造血生长因子的cDNA克隆的基础上,建立了超剂量生长因子的小鼠动物模型。有两种途径:其一是通过转基因鼠方法,让小鼠每个细胞携带
To date, 12 lineage-restricted hematopoietic growth factors have been identified and purified (they are Epo, GM-CSF, M-CSF, G-CSF, IL-1, IL-2, IL-3, IL-4 , IL-5, IL-6, IL-7 and ILF, ILF is called leukemia inhibitory factor. Due to the isolation of their respective cDNAs, a large number of recombinant growth factors with intact biological activity can be produced using genetic engineering methods and Epo, GM-CSF and G-CSF have now been subjected to extensive clinical trials. Evidence shows that the extensive use of these three factors in the patient’s body can stimulate blood sodium formation, not only can selectively regulate the generation of mature blood cells, but also stimulate the mature cells have more functional activity. Based on the cDNA cloning of mouse hematopoietic growth factor, an animal model of mouse overdosing growth factor was established. There are two ways: First, by means of transgenic mice, let each mouse cells to carry