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目的 研究丙 聚胶囊 (calciumpyruvateandchitosancapsule ,CCC)对单纯性肥胖大鼠的减肥效果 ,初步探讨其减肥机理。方法 建立营养性肥胖大鼠模型。肥胖大鼠胃饲CCC混悬液 30d ,观察CCC治疗前后体重、肥胖指数、腹腔脂肪重量、脂 体比、脂肪细胞数量、脂肪细胞大小、血脂、血清瘦素水平的变化。结果 给予CCC治疗后 ,营养性肥胖大鼠体重、肥胖指数、腹腔脂肪重量、脂 体比及脂肪细胞大小均明显低于肥胖模型组 (P <0 .0 5 ) ;血清瘦素水平明显降低 (P <0 .0 1) ;CCC高、中剂量组血甘油三酯、总胆固醇含量明显下降 (P <0 .0 5 )。结论 CCC灌服 30d对营养性肥胖大鼠有明显减肥作用 ,该作用未显示与促进血清瘦素分泌有关。CCC在减肥的同时 ,有一定的降血脂作用
Objective To study the effect of calcimumpyruvate and chitosancapsule (CCC) on weight loss in simple obese rats and to explore its mechanism of weight loss. Methods To establish a rat model of nutritional obesity. Observe the changes of body weight, fat index, intraperitoneal fat weight, fat ratio, fat cell number, adipocyte size, blood fat, serum leptin level before and after treatment of CCC for 30 days. Results After treatment with CCC, body weight, obesity index, peritoneal fat mass, fat ratio and fat cell size in obese model rats were significantly lower than those in obese model rats (P <0.05); serum leptin level was significantly lower P <0.01). The levels of triglyceride and total cholesterol in CCC high and middle dose groups decreased significantly (P <0.05). Conclusions CCC can obviously reduce weight loss in nutrition obese rats 30 d after oral administration, which has not been shown to be associated with the promotion of serum leptin secretion. CCC weight loss at the same time, there are some hypolipidemic effect