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垂直传播是乙肝的传播途径之一,可分为母婴和父婴垂直传播两种,母婴传播及如何阻断已受到广泛关注。但父婴垂直传播并未得到社会认可和重视。目前国内外研究显示,父婴传播可能是导致乙型肝炎病毒(HBV)慢性感染的重要途径之一。本文就父婴垂直传播在HBV感染的流行病学依据、动物实验和分子生物学研究进行综述,以引起研究人员和临床工作者的重视。
Vertical transmission is one of the routes of transmission of hepatitis B, can be divided into vertical transmission of mother and child and the father and the baby two kinds of mother-to-child transmission and how to block has received widespread attention. However, the vertical transmission of parents and infants did not receive social recognition and attention. At present, studies at home and abroad show that the transmission of the father to the infant may be one of the important pathways leading to the chronic infection of Hepatitis B virus (HBV). In this paper, the epidemiological basis of HBV infection, animal experiments and molecular biology studies of the vertical transmission of the father and infant were reviewed in order to arouse the attention of researchers and clinicians.