FMS-like Tyrosine Kinase 3(FLT3)是一种受体酪氨酸激酶,在造血干细胞、前体B细胞等的增殖、分化以及存活中具有重要作用。急性白血病的发病往往伴随着FLT3的异常活化,FLT3突变是造成其异常活化的主要原因,且FLT3突变的患者往往具有较差的预后。FLT3抑制剂的研究为白血病靶向治疗提供了广阔的前景。 FMS-like Tyrosine Kinase 3 (FLT3) is a receptor tyrosine kinase that plays an important role in the proliferation, differentiation and survival of hematopoietic stem cells, precursor B cells, and the like. The incidence of acute leukemia is often accompanied by the abnormal activation of FLT3, FLT3 mutation is the main reason for its abnormal activation, and patients with FLT3 mutation often have poor prognosis. The study of FLT3 inhibitors has provided broad prospects for the targeted therapy of leukemia.