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疲劳是很多内科及神经疾患的常见表现,理解这些疾病肌肉疲劳的中枢或者外周起源对制定针对性的肌肉疲劳治疗措施具有重要指导意义。综述肌肉疲劳发生的中枢因素(包括脊髓水平和激素上水平所有可以导致运动神经元兴奋性下降的因素)、外周因素(包括神经肌肉的传播、肌肉动作电位的扩散、兴奋-收缩偶联),并讨论采用直接(最大自主收缩、抽搐力)和间接(抽搐叠加、肌电图、运动皮质刺激)的检测方法评估肌肉疲劳的中枢和外周起源。
Fatigue is a common manifestation of many medical and neurological disorders. Understanding the central or peripheral origin of muscle fatigue in these conditions is of great guiding importance in the development of targeted measures of muscle fatigue. Summary of the central factors of muscle fatigue (including spinal cord and hormone levels all can lead to decreased motor neuron excitability factors), peripheral factors (including neuromuscular transmission, muscle action potential diffusion, excitation - contraction coupling) And discusses the central and peripheral origins of muscle fatigue assessed using direct (maximal voluntary contraction, twitching force) and indirect (twitch overlay, electromyography, motor cortex stimulation) detection methods.