作者从1969年4月至1984年3月对478名HBV携带者进行了5～15年的随访,他们都是HBsAg阳性者并携带该抗原达6个月以上。这些病人每6个月抽血进行HBV相关抗原、抗体和HBV DNA的检测,方法采用RPHA、ELISA、RIA、PHA,并用斑点杂交试验检测血清HBV DNA。对478名携带者平均随访了116.4个月。有36名清除了HBsAg(7.5%),其中14例出现抗HBs阳性,在抗HBs阳性病人中,1例HBeAg阳性持续5年以上,并可测到高水 From April 1969 to March 1984, the authors followed 478 HBV carriers for 5 to 15 years, all of whom were HBsAg positive and carried the antigen for more than 6 months. The patients were drawn blood every 6 months for detection of HBV-associated antigens, antibodies and HBV DNA. Serum HBV DNA was detected by dot blot hybridization using RPHA, ELISA, RIA, and PHA. 478 carriers were followed for an average of 116.4 months. Thirty-six patients had HBsAg (7.5%) cleared, of which 14 were anti-HBs positive and one of the HBeAg-positive patients was positive for anti-HBs for more than 5 years and had high water