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目的探讨双歧杆菌与莫沙必利联用治疗老年慢性功能性便秘的疗效观察。方法选取2011年3月~2013年3月西山煤电集团公司西山总院杜儿坪分院收治的老年慢性功能性便秘患者98例,依据随机数字表法均分为2组(n=49)。对照组给予莫沙必利治疗,研究组在对照组基础上联合双歧杆菌治疗,分析2组患者的临床疗效、不良反应和复发率情况。结果研究组总有效率93.88%,高于对照组的63.27%,差异有统计学意义(P<0.05);2组均出现轻微稀便、腹痛等不良反应;治疗6个月后,研究组复发率24.49%,低于对照组的57.14%,差异有统计学意义(P<0.05)。结论针对老年慢性功能性便秘患者予以双歧杆菌与莫沙必利联用治疗,效果显著,且患者的预后生活质量良好,值得临床推广应用。
Objective To investigate the efficacy of bifidobacterium combined with mosapride in the treatment of senile chronic functional constipation. Methods From March 2011 to March 2013, 98 elderly patients with chronic functional constipation who were admitted to Du Erping Branch of Xishan General Hospital of Xishan Coal and Electricity Group were divided into two groups according to random number table (n = 49). The control group was given mosapride treatment. The study group was treated with bifidobacterium on the basis of the control group, and the clinical efficacy, adverse reactions and recurrence rate of the two groups were analyzed. Results The total effective rate was 93.88% in the study group, which was 63.27% higher than that in the control group (P <0.05). There were slight adverse reactions such as loose stools and abdominal pain in both groups. After 6 months of treatment, the study group relapsed Rate of 24.49%, lower than the control group of 57.14%, the difference was statistically significant (P <0.05). Conclusion The combination of Bifidobacterium and mosapride in senile patients with chronic functional constipation has a significant effect, and the prognosis of patients with good quality of life is worthy of clinical promotion and application.