Objective: To investigate the susceptibility to some conventional and non-conventional insecticides in laboratory and field larval populations of the West Nile vector Culex pipiens L.(Cx. pipiens), the dominant species in Jeddah Province, Saudi Arabia.Methods: The tested conventional insecticides were Actikil and Pesgard, while the nonconventional ones were Bacilod, Dudim and Baycidal. Probit analysis and photomicroscopical observations were carried out to shed light on acute toxicity in laboratory and field Cx. pipiens strains.Results: Cx. pipiens were more susceptible to Pesgard(LC50: 0.045 and 0.032 mg/L)than Actikil(0.052 and 0.038 mg/L) and Bacilod(0.129 and 0.104 mg/L), for the field and laboratory strains, respectively. Results showed that treatments with the chitin synthesis inhibitor Dudim and Baycidal evoked morphological effects similar to those induced by other insect growth regulators. According to IC50 values obtained(concentration which to inhibit the emergence of 50% of mosquito adults), the compound Dudim(0.000 3 and 0.000 1 mg/L) was more effective against Cx. pipiens L. mosquitoes than Baycidal(0.000 4 and 0.000 3 mg/L) for both the field and laboratory strains, respectively.Conclusions: Our results provide baseline data to enhance control programs and orient public health decisions on the selection of pesticides against mosquito vectors in Saudi Arabia. Objective: To investigate the susceptibility to some conventional and non-conventional insecticides in laboratory and field larval populations of the West Nile vector Culex pipiens L. (Cx. Pipiens), the dominant species in Jeddah Province, Saudi Arabia. Methods: insecticides were Actikil and Pesgard, while the nonconventional ones were Bacilod, Dudim and Baycidal. Probit analysis and photomicroscopical observations were carried out to shed light on acute toxicity in laboratory and field Cx. pipiens strains. Results: Cx. pipiens were more susceptible to Pesgard Respectively. Results showed that that treatments with the chitin synthesis inhibitor Dudim (LC50: 0.045 and 0.032 mg / L) than Actikil (0.052 and 0.038 mg / L) and Bacilod (0.129 and 0.104 mg / and Baycidal evoked morphological effects similar to those induced by other insect growth regulators. According to IC50 values ​​obtained (concentration which to inhibit the emergence of 50% of mosquito adults), the compound Dudim (0.000 3 and 0.000 1 mg / L) was more effective against Cx. pipiens L. mosquitoes than Baycidal (0.000 4 and 0.000 3 mg / L) for both the field and laboratory strains, respectively. Conclusions : Our results provide baseline data to enhance control programs and orient public health decisions on the selection of pesticides against mosquito vectors in Saudi Arabia.