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目的通过1331对不良孕产史夫妇的细胞遗传学分析,探讨不良孕产史与染色体异常的关系。方法取1331对不良孕产史夫妇的外周血进行培养、制片及G显带进行染色体分析。结果 1331对不良孕产史夫妇染色体分析,发现异常核型139例,占10.44%,其中结构和数目异常有46例,染色体多态性变异有93例。结论染色体异常是导致不良孕产史的重要原因,及早发现有助于降低胎停育、自然流产、死胎等发病率,降低出生缺陷,因此,染色体分析应作为优生检查的常规项目。
Objective To investigate the relationship between the history of poor pregnancy and chromosomal abnormalities through the cytogenetic analysis of 1331 pairs of unhealthy pregnant women. Methods 1331 pairs of poor pregnancy and husband’s history of peripheral blood culture, production and G banding chromosome analysis. Results 1331 Chromosome analysis showed that there were 139 cases of abnormal karyotype (10.44%), of which 46 cases were abnormal in structure and number, and 93 cases were polymorphic variation. Conclusions Chromosomal abnormalities are the major causes of adverse pregnancy history. Early detection helps to reduce the incidence of childbirth, spontaneous abortion and stillbirth, and to reduce the birth defects. Chromosome analysis should be used as a routine item in eugenics examination.