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目的探讨在自然周期获取未成熟卵母细胞体外成熟技术(IVM)治疗多囊卵巢综合征(PCOS)性不孕症的临床疗效。方法 41例行体外受精-胚胎移植助孕的PCOS患者,共43个周期。获未成熟卵母细胞482枚,进行体外培养成熟后行单精子卵胞浆内注射,受精后取优质胚胎移植宫腔内。统计其获卵率、受精率、卵裂率和妊娠率。结果 43个周期体外培养成熟卵子320枚、成熟率为66.39%;用于受精363枚、受精329枚、受精率为90.63%卵裂279枚、卵裂率为84.80%,其中40个周期进行了胚胎移植,周期取消率为6.97%,19例患者妊娠,移植周期妊娠率44.18%。结论 IVM技术是治疗多囊卵巢综合征性不孕症的有效方法。
Objective To investigate the clinical efficacy of immature oocyte maturation technique (IVM) in the treatment of infertility with polycystic ovary syndrome (PCOS) in natural cycles. Methods A total of 41 cycles of 41 PCOS patients undergoing in vitro fertilization-embryo transfer were performed. Obtained 482 immature oocytes, in vitro maturation of sperm after intracytoplasmic sperm injection, after fertilization to take high-quality embryo transfer within the uterine cavity. Statistics of their egg yield, fertilization rate, cleavage rate and pregnancy rate. Results The results showed that there were 320 mature eggs in vitro. The maturation rate was 66.39%. There were 363 fertilized and 329 fertilized fertilizers with 279 fertilization rate of 90.63% and cleavage rate of 84.80%, of which 40 cycles were performed Embryo transfer, cycle cancellation rate was 6.97%, 19 patients pregnancy, pregnancy rate of 44.18%. Conclusion IVM is an effective method for the treatment of infertility with polycystic ovary syndrome.