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前言近年来,中枢神经系统(CNS)受体显像剂的研制取得了很大的进展,其中对放射性多巴胺受体显像剂的研究最为广泛而深入, 因为多巴胺系统不仅对维持人体正常的生理功能很重要,而且可能是抗帕金森综合征药物和抗精神分裂症药物的主要作用部位。对多巴胺受体的药理学研究比较深入。多巴胺受体根据与腺苷酸环化酶活性的相关程度以及其受体激动剂、阻滞剂作用机理的不同,至少分为两个亚型:多巴胺D_1受体和D_2受体,它们都可影响中枢神经系统多巴胺神经元的兴奋性,而且还相互作用。另外,二者在生理、生化方面亦表现出各自独特的功能。
Preface In recent years, great progress has been made in the development of CNS receptor imaging agents. Among them, the research on radioactive dopamine receptor imaging agents is the most extensive and in-depth. Because dopamine system is not only useful for maintaining normal human physiology Function is important and may be the main site of action against Parkinsonism drugs and anti-schizophrenia drugs. Pharmacological research on dopamine receptors more in-depth. Dopamine receptors are classified into at least two subtypes, dopamine D 1 receptor and D 2 receptor, depending on the degree of association with adenylate cyclase activity and the mechanism of action of their receptor agonists and blockers Affects the excitability of central nervous system dopamine neurons, but also interacts. In addition, both of them show their unique functions in physiology and biochemistry.