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目的观察低剂量吉西他滨联合顺铂治疗老年晚期非小细胞肺癌的疗效及毒副反应。方法国产吉西他滨800mg/m2,静脉滴注30min,第1、8天;顺铂14mg/m2,第1～5天,3周重复,治疗32例70岁以上的晚期非小细胞肺癌患者。结果32例患者共化疗108周期,完全缓解0,部分缓解17例(53.1%,17/32),稳定8例(25%,8/32),进展7例(21.9%,7/32),总有效率53.1%,疾病控制率(CR+PR+SD)78.1%,中位疾病进展时间5.2个月,中位生存期11.6个月。毒副作用主要为粒细胞减少、血小板下降、贫血、乏力。均可耐受。结论低剂量吉西他滨联合顺铂治疗老年晚期非小细胞肺癌的疗效肯定且患者耐受性较好。
Objective To observe the curative effect and toxicity of low-dose gemcitabine combined with cisplatin in the treatment of senile advanced non-small cell lung cancer. Methods Gestamil domestic 800mg / m2, intravenous infusion 30min, first and eighth days; cisplatin 14mg / m2, 1 to 5 days, 3 weeks repeated treatment of 32 patients over the age of 70 patients with advanced non-small cell lung cancer. Results The 32 patients were treated with 108 cycles of chemotherapy, with complete remission (0), partial remission in 17 cases (53.1%, 17/32), stabilization in 8 cases (25%, 8/32) and progression in 7 cases (21.9%, 7/32) The total effective rate was 53.1%, disease control rate (CR + PR + SD) 78.1%, median disease progression time 5.2 months, and median survival 11.6 months. The main side effects of neutropenia, thrombocytopenia, anemia, fatigue. Can be tolerated. Conclusion Low-dose gemcitabine combined with cisplatin in the treatment of elderly patients with advanced non-small cell lung cancer is effective and well tolerated.