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目的:了解卷曲霉素静脉滴注替代肌注制剂对复治痰菌阳性肺结核病人的治疗效果。方法:选复治菌阳肺结核病例,按2:1比例随机分入静滴组和肌注组,采用含卷曲霉素、异烟肼、利福平、吡嗪酰胺及乙胺丁醇等药物方案(2CHRZE/6H3R3E3)分别进行治疗。结果:卷曲霉素静滴组强化期末与满疗程结束时痰结核菌阴转率分别为70.5％,83.33％,卷曲霉素肌注组强化期末与满疗程结束时痰菌阴转率为69.6％,80.82％(P>0.05)。不良反应发生率分别为21.8％和47.1％,有显著性差异(P<0.01)。结论:硫酸卷曲霉素静脉滴注治疗复治菌阳肺结核效果不低于肌肉注射,降低了不良反应。
Objective: To investigate the therapeutic effect of intravenous injection of capreomycin instead of intramuscular injection on patients with sputum bacteremia positive pulmonary tuberculosis. Methods: The selected cases of positive pulmonary tuberculosis cases were randomly divided into intravenous drip group and intramuscular injection group according to the ratio of 2: 1. Drugs such as caprine, isoniazid, rifampin, pyrazinamide and ethambutol were used Protocol (2CHRZE / 6H3R3E3) were treated separately. Results: The negative conversion rates of sputum TB bacilli were 70.5% and 83.33% at the end of the intensive phase and the end of the full phase of the capmycine intravenous infusion respectively. The rate of sputum negative conversion was 69.6% , 80.82% (P> 0.05). The incidence of adverse reactions were 21.8% and 47.1% respectively, with significant difference (P <0.01). CONCLUSION: The intravenous injection of capreomycin sulfate in the treatment of dipyridamole positive pulmonary tuberculosis does not lower than the intramuscular injection, reducing the adverse reactions.