毛细胞白血病以对肝、脾、骨髓的恶性浸润伴不同程度的再障为主要临床特征。最常见的并发症是感染(多由罕见的细菌引起,常为死亡原因),而骨浸润极为少见,至今尚未引起人们的重视。作者报道,在46例毛细胞白血病的随访中有4例并发骨浸润。根据临床特征和在周围血、骨髓及活检标本中找到典型的毛细胞而确诊为毛细胞白血病,抗酒石酸磷酸酶染色均为阳性。4例都进行了脾切除。除例4外,在确定骨浸润前都有一个血检指标(常规+血小板)稳定期。此后一段时间内,患者均主诉局 Hairy cell leukemia with liver, spleen, bone marrow malignant infiltration with varying degrees of aplastic anemia as the main clinical features. The most common complication is infection (mostly caused by rare bacteria, often the cause of death), and bone infiltration is extremely rare and has not attracted much attention. The authors report that in 46 cases of hairy cell leukemia follow-up in 4 cases with bone infiltration. According to clinical characteristics and in the peripheral blood, bone marrow and biopsy specimens found typical hair cells were diagnosed as hairy cell leukemia, anti-tartaric acid phosphatase staining were positive. 4 cases were splenectomy. Except for Example 4, there was a stable blood test (routine + platelet) prior to bone infiltration. After a period of time, patients were chief complaint bureau