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目的 :研究颈内动脉灌注盐酸嘧啶亚硝脲 (ACNU)治疗脑恶性肿瘤的近期疗效及并发症的防治。方法 :对 115例经组织学确诊为恶性脑肿瘤患者采用患侧颈内动脉灌注ACNU ,并对照化疗前后的CT及MR表现 ,评价该化疗对恶性肿瘤的疗效。结果 :本组 115例治疗后肿瘤完全消失 10例 (16 5 % ) ,部分消失 76例 (6 6 1% ) ,稳定 15例 (13 0 % ) ,恶化 5例 (4 4% )。颈内动脉灌注ACNU可明显降低静脉给药的并发症和毒性反应。结论 :颈内动脉灌注化疗治疗恶性脑肿瘤可将药物有效浓度灌注到颅内肿瘤组织 ,减轻全身毒性反应 ,近期疗效良好
Objective: To study the short-term curative effect and prevention and treatment of intracranial arterial infusion of pyrimidine nitrous oxide hydrochloride (ACNU) in the treatment of malignant brain tumors. Methods: A total of 115 patients with histologically diagnosed malignant brain tumor were infused with ipsilateral internal carotid artery and compared with CT and MR before and after chemotherapy. The curative effect of this chemotherapy on malignant tumor was evaluated. Results: Totally 115 cases (165%) disappeared completely in 76 cases (661%), stable in 15 cases (13%) and deteriorated in 5 cases (44%) in 115 cases of this group. Internal carotid artery perfusion ACNU can significantly reduce the complications and toxicity of intravenous administration. Conclusion: Intra-arterial infusion chemotherapy in the treatment of malignant brain tumors can be effective concentrations of drug infusion to intracranial tumors, reduce systemic toxicity, the recent good effect