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目的观察曲美他嗪对稳定型心绞痛的疗效。方法 100例稳定型心绞痛患者随机分为治疗组和对照组各50例,对照组应用硝酸酯类、β-受体阻滞剂和钙离子拮抗剂等常规治疗;治疗组在常规治疗基础上加服曲美他嗪(20mg,3次/天);疗程12周。结果和对照组比较,治疗组:①心绞痛发作次数及硝酸甘油量均明显减少(P<0.01);②运动持续时间延长(P<0.05),运动总工作量增加(P<0.01),至心绞痛发作时间及ST段下降1mm的时间均明显延长(P<0.01);③应用曲美他嗪12周内上腹部不适1例、头痛1例、面红1例、心悸1例。结论曲美他嗪治疗稳定型心绞痛疗效显著、安全。
Objective To observe the effect of trimetazidine on patients with stable angina pectoris. Methods 100 patients with stable angina pectoris were randomly divided into treatment group and control group, 50 cases in each group. The control group was treated with nitrates, β-blockers and calcium antagonists. The treatment group was given conventional treatment Trimetazidine service (20mg, 3 times / day); treatment for 12 weeks. Results Compared with the control group, the number of angina attacks and the amount of nitroglycerin in the treatment group were significantly decreased (P <0.01); ② The duration of exercise was prolonged (P <0.05); the total exercise workload was increased (P <0.01) (P <0.01). (3) Trimetazidine did not cause upper abdominal discomfort in 12 weeks, headache in 1 case, redness in 1 case and heart palpitations in 1 case. Conclusion Trimetazidine is effective and safe in the treatment of stable angina pectoris.