目的探讨性染色体异常与男性不育之间的关系。方法对在我院遗传咨询、生殖健康、育前检查门诊中,男性不育患者236例,作外周血淋巴细胞培养,染色体核型分析。结果发现性染色体异常核型36例,检出率为15.3%。其中数目异常核型20例,占55.6%,结构异常3例,占8.3%,多态性变异13例,占36.1%。结论性染色体异常是导致男性不育的重要原因。 Objective To explore the relationship between sex chromosome abnormalities and male infertility. Methods In our hospital genetic counseling, reproductive health, prenatal care check-up of 236 cases of male infertility, peripheral blood lymphocyte culture, chromosome karyotype analysis. Results showed that there were 36 cases of abnormal chromosomal karyotype, the detection rate was 15.3%. The number of abnormal karyotype in 20 cases, accounting for 55.6%, 3 cases of structural abnormalities, accounting for 8.3%, 13 cases of polymorphic variation, accounting for 36.1%. Conclusions Sexual chromosomal abnormalities are the major causes of male infertility.