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用双盲方法观察34例非胰岛素依赖型糖尿病（NIDDM）患者口服卡托普利（CPT）或安慰剂治疗对糖代谢、胰岛素水平、甲状腺、肾上腺皮质功能的影响。表明：（1）用CPT治疗2wk后NIDDM患者的空服和餐后血糖均降低，CPT与降糖药合用血糖下降更明显，说明CPT对NIDDM患者有降糖作用，并与降糖药有协同作用，（2）CPT治疗前后血清胰岛素无显著差异，说明CPT的降糖作用不是通过刺激胰岛素分泌来实现的；（3）CPT治疗后血FT3、FT4、皮质醇等胰岛素拮抗激素的浓度降低是其降糖作用原理之一。
The effects of oral captopril (CPT) or placebo on glucose metabolism, insulin level, thyroid and adrenocortical function in 34 patients with non-insulin dependent diabetes mellitus (NIDDM) were observed by double-blind method. The results showed that: (1) After 2 weeks of treatment with CPT, the emptying and postprandial blood glucose of NIDDM patients decreased, and the combined blood glucose of CPT and hypoglycemic agents decreased more obviously, indicating that CPT had hypoglycemic effect on NIDDM patients and was synergistic with hypoglycemic agents (2) there was no significant difference in serum insulin before and after CPT treatment, indicating that hypoglycemic effect of CPT was not achieved by stimulating insulin secretion; (3) the concentration of insulin antagonist hormone such as FT3, FT4 and cortisol decreased after CPT treatment Its hypoglycemic effect of one of the principles.