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目的:调查高原慢性习服群体公路护路职工的高原红细胞增多症达到血液学诊断标准的患病率,揭示其性激素、免疫、血细胞的特征性改变及其生理与病理的关联。方法:随机抽取海拔(2 800~2 900)m、(3 600~3 740)m、(4 250~4 300)m护路职工189名,用免疫速率散射比浊法测定血清IgG、IgM、IgA含量,Epics XL流式细胞仪测定CD3、CD4、CD8,d iff2全自动血细胞分析仪测定21项血细胞,ACS180化学发光仪测定性激素FSH、LH、E2、P、PRL、T。结果:方差统计三个海拔梯度人群Hb≥210g/L者检出率分别为4.50%、17.20%和44.12%;同时与未患病组对照,偏相关、线性回归分析显示密切关联着特征性的LH降低、E2升高、PLT减少、Hct增高;还伴有一定相关的FSH、CD3、CD4、IgM、WBC、RBC升高和CD4/CD8比值减小。结论:在高原低氧环境中从事劳动强度较大的护路人群有较高Hb≥210g/L的检出率;Hb过度增生与这几方面存在着生理与病理的互相关联。
OBJECTIVE: To investigate the prevalence of high altitude polycythemia patients reaching hematological diagnostic criteria for workers in high altitude chronic adherence group and to reveal the changes of their sex hormones, immunity, blood cells and their correlation with their physiology and pathology. Methods: A total of 189 workers in the road maintenance workers (2 800 ~ 2 900 m), (3 600 ~ 3 740 m) and (4 250 ~ 4 300 m) m road workers were randomly selected for serum IgG and IgM, IgA content, Epics XL flow cytometry CD3, CD4, CD8, d iff2 automatic hematology analyzer measured 21 blood cells, ACS180 chemiluminescence instrument for the determination of sex hormones FSH, LH, E2, P, PRL, Results: Variance statistics showed that the detection rates of Hb≥210g / L were 4.50%, 17.20% and 44.12% respectively in the three altitudinal gradient groups, while partial correlation and linear regression analysis showed that there was a close correlation with the characteristic LH, E2 increased, PLT decreased, Hct increased; also associated with a certain correlation of FSH, CD3, CD4, IgM, WBC, RBC increased and CD4 / CD8 ratio decreased. Conclusions: The detection rate of Hb≥210g / L is higher in the road workers who work in the labors with high labor intensity in the plateau hypoxia environment. Hb hyperproliferation is related to the physiological and pathological aspects in these areas.