小鼠灌胃7和14mg/kg肼,血中肼浓度的时相为一级吸收一空模型,而消化道中肼的累积消除过程符合非线性动力学;静脉注射7mg/kg肼呈二室模型。肼经小鼠消化道吸收入血很快,吸收率为82～85％,但经灌胃进入消化道的肼却能够被全部消除,消除灌胃剂量的一半所需时间不到3min,至1h基本被全部消除;当血中吸收相基本结束时,灌胃剂量的79～83％已从消化道中被消除,与吸收率近似。肼在小鼠体内分布极快,呈周身分布,可能有“富集”部位。肼从小鼠体内消除快,物质蓄积性弱。 Mice were fed 7 and 14 mg / kg hydrazine, the phase of the concentration of hydrazine in the blood was the first-level absorption-empty model, and the cumulative elimination of hydrazine in the digestive tract was in accordance with the nonlinear kinetics. Intravenous injection of hydrazine at 7 mg / kg showed a two-compartment model. Hydrazine by the mouse digestive tract absorbed into the blood quickly, the absorption rate of 82 to 85%, but by gavage into the digestive tract of hydrazine can be completely eliminated, half the dose of gavage to eliminate less than 3min, to 1h Basically disappeared; when the blood absorption phase is basically completed, the gavage dose of 79 to 83% has been eliminated from the digestive tract, and the absorption rate is similar. Hydrazine distribution in mice extremely fast, was the whole body distribution, there may be “enrichment” parts. Hydrazine from the body to eliminate mice quickly, weak accumulation of material.