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目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者静息态不同频段下低频振幅(ALFF)脑自发活动的特点。方法 40例OSAS患者及40名正常睡眠志愿者(GS)进行静息态下脑功能磁共振(f MRI)数据采集。计算两个频段slow-4(0.027~0.073 Hz)和slow-5(0.01~0.027 Hz)ALFF信号值。采用SPM8软件进行两因素水平方差分析比较组间及频段间主效应ALFF值的差异。采用两样本t检验分别比较组间两个频段ALFF值的差异,同时分析ALFF值差异脑区与临床量表的相关性。结果与GS组相比,OSAS组双侧楔前叶、后扣带回、左侧颞中回、右侧角回及顶下小叶ALFF值显著减低(P﹤0.05);而双侧颞下回、梭状回、左侧眶部额下回、颞上极及双侧辅助运动区ALFF值显著增高(P﹤0.05)。与slow-5频段相比,slow-4频段左侧颞上极ALFF值显著增高;而左侧眶部额下回,双侧额中回,直回ALFF值显著减低。OSAS患者组slow-4频段比slow-5频段显示更广泛ALFF差异脑区包括右侧角回、顶下小叶,双侧颞中回及额中回,左侧眶部额下回。结论 OSAS患者存在多个脑区神经元内在自发活动异常,部分脑区脑自发活动存在频率依赖性,slow-4频段对检测OSAS患者的脑自发活动更敏感。
Objective To investigate the characteristics of spontaneous activity of low frequency amplitude (ALFF) brain in patients with obstructive sleep apnea syndrome (OSAS) at rest and in different frequency bands. Methods Forty patients with OSAS and 40 normal sleep volunteers (GS) underwent resting magnetic resonance imaging (f MRI) data acquisition. Calculate ALFF signal values for slow-4 (0.027 to 0.073 Hz) and slow-5 (0.01 to 0.027 Hz) for both bands. The two-factor analysis of variance (ANOVA) was performed using SPM8 software to compare the differences of main effect ALFF between groups. Two samples t-test were used to compare the ALFF values of the two bands between the two groups respectively. Meanwhile, the correlation between ALFF values and clinical scales was analyzed. Results Compared with GS group, the ALFF of the bilateral wedge anterior, posterior cingulate gyrus, left middle temporal gyrus, right lateral gyrus and parietal lobule in OSAS group was significantly lower than that in GS group (P <0.05) , Fusiform gyrus, inferior frontal orbital frontal lobe, superior temporal epithelium and bilateral aortic motor area ALFF values were significantly higher (P <0.05). Compared with the slow-5 frequency band, the ALFO value on the left temporal side of the slow-4 frequency band was significantly increased; The slow-4 frequency band of OSAS patients showed a wider range than the slow-5 frequency band. ALFF differential brain regions include the right angle, the inferior parietal lobule, the bilateral middle temporal gyrus, the middle frontal gyrus and the inferior frontal orbital. CONCLUSIONS: There is a spontaneous spontaneous activity abnormality in neurons of multiple brain regions in OSAS patients. There is a frequency-dependent spontaneous activity in some brain regions. The slow-4 frequency band is more sensitive to the spontaneous activity of brain in OSAS patients.