目的探讨胰性脑病(PE)的临床特点和诊疗规律。方法结合有关文献回顾分析急性胰腺炎(AP)并发PE 20例的临床资料。结果本组20例重症胰腺炎并发PE患者中,死亡9例,治愈出院者11例,死亡率为45%,其中接受手术者10例,死亡3例;非手术者10例,死亡6例。结论重症胰腺炎(SAP)的发生与胰酶、炎症介质及感染等因素有关,治疗除手术、抑制胰酶分泌、抗感染、支持方法外,辅以强有力的脱水剂、中枢神经营养药、激素冲击治疗至关重要。 Objective To investigate the clinical features and diagnosis and treatment of pancreatic encephalopathy (PE). Methods Combined with the literature review of the clinical data of 20 cases of acute pancreatitis (AP) complicated by PE. Results Of the 20 patients with severe pancreatitis complicated with PE, 9 were dead and 11 were discharged. The mortality rate was 45%. Among them, 10 received surgery and 3 died; 10 were non-operative and 6 died. Conclusion The occurrence of severe pancreatitis (SAP) is associated with pancreatic enzymes, inflammatory mediators and infections. In addition to surgery, inhibition of pancreatic enzyme secretion, anti-infective and supportive measures, combined with potent dehydrating agents, central neurotrophic drugs, Hormone impact treatment is crucial.