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目的 探讨克罗米芬兴奋试验结果与体外受精—胚胎移植(invitrofertilization-embryotransfer,IVF-ET)结局的关系。 方法对2000年6月～2001年5月在我院生殖医学中心首次行IVF或单精子卵胞浆内注射 (ICSI)治疗的不孕患者67例作前瞻性研究 ,在IVF治疗前1～3个月行克罗米芬兴奋试验。结果 24例为异常反应 ,其中15例患者基础FSH位于正常范围 ,43例患者为正常反应 ,异常反应组的基础及克罗米芬兴奋后的FSH水平明显高于正常反应组(p<0.001) ,两组的基础及克罗米芬兴奋后的LH、E2水平 ,差异均无统计学意义。克罗米芬兴奋试验反应异常组与反应正常组相比 ,IVF的妊娠率明显低 ,并有较高的周期取消率。结论 克罗米芬兴奋试验能预测IVF的结果。
Objective To investigate the relationship between the results of clomiphene and the outcome of in vitro fertilization-embryotransfer (IVF-ET). Methods Sixty-seven cases of infertility treated with IVF or intracytoplasmic sperm injection (ICSI) for the first time in our hospital from June 2000 to May 2001 were prospectively studied. Before the IVF treatment, 1 to 3 Month Clomiphene trip excited test. Results Of the 24 cases, abnormal FSH was found in all the patients. The basal FSH of 15 patients was normal and 43 patients were normal. The basal level of FSH and the FSH level of clomiphene were significantly higher than those of normal group (p <0.001) The basis of group and clomiphene after excitement of LH, E2 levels, the difference was not statistically significant. Clomiphene stimulation test abnormal response group compared with normal control group, IVF pregnancy rate was significantly lower, and a higher rate of cycle cancellation. Conclusion Clomiphene’s excitement test can predict the outcome of IVF.