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地戈辛(Digoxin)是广泛应用于临床治疗心衰的重要药物。由于临床用药剂量小,治疗量与中毒量又非常接近,易导致药物中毒。开展临床地戈辛血药浓度监测,指导临床安全、合理用药是十分必要的。临床使用的国产地戈辛片剂,往往来自不同制剂厂或同厂不同批号,药物在生物体中的吸收利用程度亦不尽相同,甚至出现很大的差异,而致使生物不等效。为全面、正确地评价药物制剂质量
Digoxin is an important drug that is widely used in the clinical treatment of heart failure. Due to the small dose of clinical medication, the amount of treatment and poisoning is very close, easily lead to drug poisoning. It is very necessary to carry out clinical monitoring of blood concentration of Gocin, to guide clinical safety and rational use of drugs. Domestic gekinen tablets used in clinical practice often come from different batch factories or different batches of the same plant, and the absorption and utilization levels of the drugs in the organism are not the same even with great differences, resulting in inequalities of organisms. To comprehensively and correctly evaluate the quality of pharmaceutical preparations