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目的:探讨坎地沙坦与依那普利联合应用对高血压合并左心室肥厚患者血压及左室重构的影响。方法:选择65例高血压合左心室肥厚患者为研究对象,随机分为2组,分别给予坎地沙坦和坎地沙坦与依那普利联合治疗,疗程共26周。采用彩色超声技术测定治疗前、后左心室肥厚的参数变化,并记录血压的变化。结果:坎地沙坦与依那普利联合应用能明显改善高血压患者左室舒张功能,逆转左室肥厚(P<0.05);坎地沙坦单用或与依那普利联合应用均能明显降低血压(P<0.05),但二者联合应用的降压效果与坎地沙坦单独应用的效果相比,差异没有显著性意义(P>0.05)。结论:坎地沙坦与依那普利联合应用具有较好的降压效果,并能明显阻断心室重构、改善心脏功能。
Objective: To investigate the effect of combination of candesartan and enalapril on blood pressure and left ventricular remodeling in patients with hypertension and left ventricular hypertrophy. Methods: Sixty-five hypertensive patients with left ventricular hypertrophy were selected and randomly divided into two groups. The patients were given candesartan and candesartan in combination with enalapril for 26 weeks. The changes of parameters of left ventricular hypertrophy before and after treatment were measured by color sonography, and the changes of blood pressure were recorded. Results: The combination of candesartan and enalapril could significantly improve left ventricular diastolic function and reverse left ventricular hypertrophy in hypertensive patients (P <0.05). Candesartan alone or combined with enalapril (P <0.05). However, there was no significant difference between the two groups in the antihypertensive effect of candesartan alone (P> 0.05). Conclusion: The combination of candesartan and enalapril has a good antihypertensive effect, and can obviously block ventricular remodeling and improve cardiac function.