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为了确定作者等1975年从四川西昌克山病流行区一个亚急克山病儿分离出来的川便5病毒与克山病的关系,我们于1990年4～6月进行了克山病血清流行病学调查。调查对象为吉林省长白朝鲜族自治县既往克山病人54例(包括慢性克山病和潜在性克山病各2例),非克山病人54例和非病区长春市非克山病人42例。所用方法为微量中和试验法。调查结果:(1)在川便5病毒与克山病之间存在特异的、此病毒抗原与长白县既往克山病人血内抗体相符合的关系,因此我们认为川便5病毒可能是克山病致病因素之一。(2)川便5与标准Echo_6病毒虽属同一个血清型,但它们的抗原性和致病性是不同的,无论在前者或后者方面,川便5病毒均显著高于标准Echo_6病毒;所以川便5病毒可能是Echo_6病毒的一个新亚型,即Echo_(6-3)。
In order to determine the relationship between Chuanxian 5 virus and Keshan disease, which was isolated from a sub-acute mountain sick child in Kakeama disease in Xichang, Sichuan Province in 1975, we conducted a Keshan disease seropositivity in April-June 1990 Surveying. The subjects of investigation were 54 cases of Keshan patients (including 2 cases of chronic Keshan disease and 2 cases of potential Keshan disease) in Changbai Korean Autonomous County of Jilin Province, 54 cases of non-Keshan disease and 42 cases of non-Keshan patients in Changchun . The method used is micro-neutralization test. Findings: (1) There is a specific relationship between Kawasaki-5 virus and Keshan disease, and this virus antigen is consistent with the intra-blood antibody of Keshan patients in Changbai County. Therefore, we think Kawasake-5 virus may be Keshan One of the disease-causing factors. (2) Chuan-bao 5 has the same serotype as the standard Echo_6 virus but their antigenicity and pathogenicity are different. Chuan-bao 5 is significantly higher than the standard Echo_6 virus in both the former and the latter. Therefore, Chuan-5 virus may be a new subtype of Echo_6 virus, Echo_ (6-3).