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目的观察环磷酰胺(CTX)冲击疗法治疗难治性肾痛综合症疗效。方法选择23例难治性肾病综合症患者,分别给予环磷酰胺冲击治疗,第一次用0.4g加入生理盐水250毫升静滴,一月后改为0.8g加入生理盐水500毫升中静滴,连用六个月,然后每三个月一次,堆持缓解半年至一年后停药,总量6～8g,CTX冲击同时联合应用强的松龙50mg/日,顿服4～6用。结果经上述治疗后,24h尿蛋白定量有明显降低,血浆总蛋白及白蛋白不同程度升高,血肌奸及内生肌酐清除冲击前后无显著差异(P>0.05)。结论CTX冲击疗法对难治性肾病综合症疗效显著,缓解率高,副作用相对较小,是目前治疗该病较为有效的方法。
Objective To observe the effect of cyclophosphamide (CTX) shock therapy in the treatment of refractory renal pain syndrome. Methods Twenty-three patients with refractory nephrotic syndrome were selected and treated with cyclophosphamide respectively. For the first time, 250 ml intravenous infusion of 0.4 g normal saline and 1 ml intravenous infusion of 0.5 g normal saline were added after one month. Used six months, and then once every three months, heap remission six months to a year after the withdrawal of a total of 6 ~ 8g, CTX impact combined with prednisolone 50mg / day, Dayton clothing 4 to 6 use. Results After the above treatments, the urinary protein excretion was significantly reduced in 24 h, and the levels of total protein and albumin in plasma were increased to varying degrees. There was no significant difference between before and after blood creatinine clearance and endogenous creatinine clearance (P> 0.05). Conclusion CTX impact therapy has significant curative effect on refractory nephrotic syndrome, high remission rate and relatively low side effects, which is the most effective method for the treatment of this disease.