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目的比较分析罗哌卡因和左旋布比卡因分别联合舒芬太尼用于分娩镇痛的疗效和安全性。方法随机选取采用罗哌卡因或左旋布比卡因联合舒芬太尼应用于足月阴道分娩产妇80例,包括:罗哌卡因组(A组)40例,左旋布比卡因组(B组)40例,选择同期条件相似未予镇痛的产妇40例作为对照组(C组),对比分析镇痛效果及其对产程和母婴的影响。结果两镇痛组均取得良好镇痛效果(P<0.05),第一产程、总产程时间(min)A组(486±202,554±197)、B组(491±190、564±187)均显著长于C组(363±168,429±175)(P<0.05),产后出血量(ml)A组(269±60)、B组(260±79)均显著高于C组(220±52)(P<0.05),余均无组间差异。结论罗哌卡因和左旋布比卡因分别联合舒芬太尼用于分娩镇痛均可取得良好的镇痛效果,但可延长产程时间及增加产后出血量,对新生儿结局无明显影响。
Objective To compare the efficacy and safety of ropivacaine and levobupivacaine combined with sufentanil for labor analgesia. Methods 80 cases of vaginal delivery women who were treated with ropivacaine or levobupivacaine combined with sufentanil were randomly selected, including 40 cases of ropivacaine (group A), 40 cases of levobupivacaine Group B). Forty patients with similar analgesia at the same period were selected as the control group (Group C). The analgesic effects and their effects on labor and maternal and infant were compared. Results Both groups had good analgesia effect (P <0.05). The first labor, the total labor duration (min) in group A (486 ± 202,554 ± 197) and group B (491 ± 190,564 ± 187) were significantly (363 ± 168,429 ± 175), postpartum hemorrhage (ml) in group A (269 ± 60), group B (260 ± 79) were significantly higher than those in group C (220 ± 52) (P <0.05), the remaining no differences between groups. Conclusion Both ropivacaine and levobupivacaine combined with sufentanil for labor analgesia can achieve good analgesic effect, but can prolong the labor time and increase the amount of postpartum hemorrhage, and have no significant effect on the neonatal outcome.