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目的：探讨乙型肝炎病毒相关肝癌患者血清白介素28B(IL-28B)表达及意义研究。方法选取慢性HBV感染的患者90例，作为研究组，另选取同期20例健康志愿者作为对照研究组，检测血清IL-28B及甲胎蛋白（AFP）值等指标。结果肝癌组IL-28B及AFP均较高，P<0.05，有统计学意义。IL-28B检测值与肝癌患者肿瘤数目有一定的关联，不同肿瘤数目组间比较差异有统计学意义，P＜0.05。结论结合AFP检测，可更加准确的诊断由乙型肝炎病毒导致的相关肝癌，值得临床检验继续深入探索。“,”Objective: To investigate serum interleukin 28B (IL-28B) expression and significance in hepatitis B virus-related hepatocel ular carcinoma in patients. Methods: 90 patients with chronic HBV infection were selected as the study group, and another 20 healthy volunteers during the same period were also selected as the control group. The serum IL-28B and AFP values and other indicators were detected. Results: The IL-28B and AFP of the HCC group were statistical y significant higher than that of other groups(P<0.05). And there was statistical y significant association between the IL-28B value and the number of hepatocel ular carcinoma tumor in patients(P<0.05). Conclusion: The combination of AFP detection could more accurately improve the diagnosis of liver cancer caused by hepatitis B virus, worthy of clinical testing to continue in-depth exploration.