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目的 探讨持续性工作紧张与工作紧张程度变化对抑郁症状的影响.方法 采用前瞻性队列研究方法,对上海市1 081名职业人群进行为期3年追踪随访.工作紧张评估采用工作内容问卷(JCQ),同时调查社会人口特征与个体行为因素.抑郁症状使用美国国立卫生研究所编制的流行病学研究抑郁量表(CESD),计算社会人口特征因素及不同职业紧张程度的抑郁症状发生率.同时采用非条件logistic回归方法,在调整影响抑郁症状相关混杂因素的条件下,分析3年工作紧张程度的变化对抑郁症状的影响.结果 3年肯定抑郁症状阳性率为8.79％.持续性工作紧张可增加抑郁症状的风险,RR值2.213 (95％CI:1.192～4.119);持续性的低社会支持亦为抑郁症状的危害因素RR值1.978 (95％CI:1.110～3.544);工作紧张程度变化与抑郁症状也存在联系,相对于初次和随访均为低工作紧张,从低工作紧张到高工作紧张,RR值2.985 (95％CI:1.466～ 6.077),初次和随防均为高度紧张,RR值2.665 (95％CI:1.405～ 5.053).结论 持续性工作紧张和工作紧张程度上升可增大职业人群抑郁症状的风险.“,”Objective To explore the influence of chronic work stress on the symptoms of depression in occupational population.Methods This prospective 3 year follow up study included 1081 working individuals aged 23-63 years recruited from 3 occupational groups in Shanghai,China.The Chinese version of Karasek's job content questionnaire (JCQ) was used for the assessment of work stress and the Chinese version of Center for Epidemiological Survey Depression Scale (CES D) questionnaire was used to assess depression symp toms.Logistic regression analysis was used to determine the associations between depression symptoms and psychosocial work environment factors after adjusting the confounder variables.Results The prevalence of symptomatic depression among working population was 8.79 ％ during 3 year study period.Chronic work stress and low social support were associated with increased risk of depressive symptoms with the OR of 2.213 (95 ％ CI:1.192 4.119) and 1.978 (95％CI:1.110-3.544),respectively.Both work stress change from low to high and all time high work stress were positively related to depressive symptoms after adjustment for earlier psychological confounder variables.Conclusions Persistent work stress and stress change from low to high are risk factors for symptomatic depression among working individuals.