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在建立３２Ｐ胶体间质内放疗动物模型实验的基础上，在间质内放疗剂量４００Ｇｙ时腹腔内应用氯胺酮和戊巴比妥，以观察内放疗周围脑组织损伤的保护作用。结果表明：在ＭＲＴ２ＷＩ像上水肿范围以及多胺ＳＰｄ含量上，氯胺酮处理组与正常对照组无显著差异，而戊巴比妥处理组（１０ｍｇ腹腔ｑｄ）和正常对照组以及氯胺酮组存在差异，提示氯胺酮对３２Ｐ胶体间质内放疗脑组织损伤无明显保护作用，而戊巴比妥具有明显保护作用，并和多胺中ＳＰｄ减少有关。
On the basis of establishing 32P colloid interstitial radiotherapy animal model experiment, ketamine and pentobarbital were intraperitoneally administered at the dose of 400Gy in order to observe the protective effect of intracerebral radiotherapy on brain injury. The results showed that there was no significant difference between the ketamine group and the normal control group on the extent of edema on the MRT2WI image and the content of polyamine SPd, but there was a difference between the pentobarbital group (10 mg peritoneal qd) and the normal control group and the ketamine group Ketamine had no significant protective effect on brain injury induced by 32P colloid interstitial radiation, while pentobarbital had a significant protective effect and was related to the decrease of SPd in polyamines.