血管内皮细胞结构和功能的异常是糖尿病大血管动脉粥样硬化形成及微血管病变早期的关键因素.PPARγ配体除了能增强周围组织对胰岛素的敏感性、降低血糖外,还通过舒张血管、减轻炎症、抗氧化应激等作用与调节血管内皮细胞功能紧密相关. The abnormality of the structure and function of vascular endothelial cells is a key factor in the early formation of atherosclerosis and angiogenesis in diabetic macrophages.PPARγ ligand can not only increase the sensitivity of surrounding tissues to insulin but also decrease blood glucose, , Anti-oxidant stress and other functions and regulation of vascular endothelial cell function is closely related.