胎儿先天性畸形的发生率约为2%,其中30%的畸胎与染色体异常有关,60%以上由药物所致。根根药物的药动学、理化性质、脂溶性、分子大小及结合率等因素,妊娠期抗菌药物的使用可分如下三类。妊娠期忌用的抗菌药物:包括氨基甙类、多粘菌素、万古霉素、四环素类、抗霉菌药(氟胞嘧啶、两性霉素B、灰黄霉素等)及5-硝基咪唑类。氨基甙类可引起耳及肾 The incidence of congenital malformations of fetus is about 2%, of which 30% of teratospermia and chromosomal abnormalities, more than 60% caused by the drug. Pharmacokinetics, physicochemical properties, lipid solubility, molecular size and binding rate and other factors, the use of antibiotics in pregnancy can be divided into the following three categories. Antibacterial drugs used in pregnancy include: aminoglycosides, polymyxin, vancomycin, tetracyclines, antimycotics (flucytosine, amphotericin B, griseofulvin, etc.) and 5- nitroimidazole class. Aminoglycosides can cause ears and kidneys