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目的了解海口地区疑似生殖器疱疹患者单纯疱疹病毒(HSV)感染情况。方法用核酸PCR-荧光探针法对本院1 312例疑似生殖器疱疹患者进行HSV-1/2型基因检测。结果 1 312例疑似生殖器疱疹患者中,HSV-1型阳性22例,阳性率1.68%(22/1 312),HSV-2型阳性621例,阳性率47.33%(621/1 312),单纯疱疹病毒阳性共643例,阳性率49.01%(643/1 312),无合并感染者。643例HSV阳性患者,有典型临床症状(溃疡、结痂、水疱等)426例,占66.25%;无症状217例,占33.75%。HSV-1型阳性率与HSV-2型阳性率比较,差异有统计学意义(P<0.01)。643例单纯疱疹病毒感染者中,男465例,阳性率49.47%(465/940),女178例,阳性率47.85%(178/372),男女阳性率差异无统计学意义(P>0.05)。结论海口地区疑似生殖器疱疹患者HSV阳性检出率高,感染有型别差异,以HSV-2为主。无症状HSV感染者占1/3,提示临床应重视对疑似生殖器疱疹患者进行HSV基因检测,避免误诊漏诊。HSV感染率无性别差异。
Objective To understand the herpes simplex virus (HSV) infection in patients with suspected genital herpes in Haikou. Methods HSV-1/2 gene was detected in 13 312 cases of suspected genital herpes in our hospital by nucleic acid PCR-fluorescence probe. Results Among the 1 312 cases of suspected genital herpes, 22 were positive for HSV-1, the positive rate was 1.68% (22/1 312). The positive rate of HSV-2 was 621, the positive rate was 47.33% (621/1 312) A total of 643 positive cases of the virus, the positive rate of 49.01% (643/1 312), without infection. Among the 643 HSV-positive patients, there were 426 cases (66.25%) with typical clinical symptoms (ulcers, crusting and blisters); 217 cases were asymptomatic (33.75%). HSV-1 positive rate and HSV-2 positive rate, the difference was statistically significant (P <0.01). Among 643 cases of herpes simplex virus infection, 465 males were positive, with a positive rate of 49.47% (465/940) and 178 females, with a positive rate of 47.85% (178/372). There was no significant difference between male and female positive rates (P> 0.05) . Conclusions The positive detection rate of HSV in suspected genital herpes in Haikou area is high, with the type of infection being different, mainly HSV-2. Asymptomatic HSV infection accounted for 1/3, suggesting that clinical should pay attention to the suspected genital herpes HSV gene test to avoid misdiagnosis. There is no gender difference in HSV infection rate.